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A novel stage-specific glycosomal nucleoside diphosphate kinase from Trypanosoma cruzi, (2017-02)
Cámara, María de los Milagros; Bouvier, León; Reigada, Changal; Digirolamo, Fabio; Saye, Melisa; Pereira, Claudio
Instituto: Instituto de Tecnología Subject: Biología; Parasitología; Enfermedades; Enfermedad de Chagas; Mucinas de T. Cruzi; Biotecnología extension: 7 p. Area de investigación: Parasitología Línea de investigación: Biología Molecular Responsable del proyecto: Cámara, María de los Milagros Nombre del proyecto: Caracterización funcional de las proteínas de tipo mucina de T. cruzi Código del proyecto: BSR174
Abstract:
Nucleoside diphosphate kinases (NDPK) are key enzymes involved in the intracellular nucleotide maintenance in all living organisms, especially in trypanosomatids which are unable to synthesise purines de novo. Four putative NDPK isoforms were identified in the Trypanosoma cruzi Chagas, 1909 genome but only two of them were characterised so far. In this work, we studied a novel isoform from T. cruzi called TcNDPK3.